David A. Sinclair, A.O., Ph.D.

Professor of Genetics, Harvard Medical School
President, Academy for Health and Lifespan Research
Author & Host, Lifespan Book & Podcast

Mission: extend healthy lifespan for all.

“One of the 100 Most Influential People in the World.”
TIME magazine

Latest Research

“Loss of epigenetic information as a cause of mammalian aging”

In this pioneering study published January 12, 2023 in Cell, Professor Sinclair and colleagues report that loss of epigenetic information causes and accelerates aging, and that these changes are reversible via epigenetic reprogramming. This finding supports Professor Sinclair’s Information Theory of Aging–and the notion that aging is reversible.

“Reprogramming to recover youthful epigenetic information and restore vision”

As detailed in this landmark study published December 2, 2020 in Nature, Professor Sinclair and colleagues have used epigenetic reprogramming to reverse vision loss in aged mice afflicted with glaucoma. This feat demonstrates that epigenetic reprogramming can be used to promote tissue regeneration and improve tissue function in live animals.

Lifespan: Why We Age-and Why We Don’t Have To

A New York Times & International Bestseller
“Brilliant and enthralling.” –Wall Street Journal

In this groundbreaking book, Professor Sinclair takes the reader to the frontlines of aging research and reveals incredible breakthroughs—many from his own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging.

Through a page-turning narrative, Professor Sinclair invites the reader into scientific discovery and discusses the emerging technologies and lifestyle changes that have been shown to help us live younger and healthier for longer.

Lifespan with Dr. David Sinclair

Peak #1 Health & Fitness show, Apple Podcasts

Join Professor Sinclair & co-host Matthew LaPlante in Lifespan, a popular health podcast that brings the cutting edge of longevity science straight to you. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise & nutrition science, and more.

Topics covered include: the science behind why we age; what to eat & when to eat for longevity; exercise science; metformin and other longevity molecules; cosmetic science for looking younger; keeping the brain healthy; biotracking & age reversal; and more.